What precautions must be taken when administering Promethazine intravenously?

When administering Promethazine intravenously, ensuring IV patency is crucial for safe administration; this involves checking that the IV line is clear and functioning properly to prevent complications such as phlebitis or extravasation. Diluting Promethazine with 10ml of normal saline is recommended to reduce the risk of local irritation at the injection site, which can occur with undiluted solutions. Additionally, administering the medication through a freely flowing infusion allows for a controlled delivery, decreasing the likelihood of adverse effects and ensuring that the medication is appropriately delivered into the bloodstream. These precautions are essential for maximizing the safety and effectiveness of Promethazine during intravenous administration.